Antibody data
- Antibody Data
- Antigen structure
- References [81]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11714-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11714-1-AP, RRID:AB_2295684
- Product name
- IFITM3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFITM3 antibody (Cat. #11714-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.
IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization.
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
A human apolipoprotein L with detergent-like activity kills intracellular pathogens.
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice.
The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3.
Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages.
Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells.
IFITM3 affects the level of antibody response after influenza vaccination.
Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells.
IFITMs of African Green Monkey Can Inhibit Replication of SFTSV but Not MNV In Vitro.
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Escape of HIV-1 envelope glycoprotein from the restriction of infection by IFITM3.
An Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses.
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells.
IFITM3 directly engages and shuttles incoming virus particles to lysosomes.
Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro.
IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells.
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1.
Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins.
Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression.
The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection.
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
IFITM3 Restricts Human Metapneumovirus Infection.
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus.
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells.
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
IFITM3 requires an amphipathic helix for antiviral activity.
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins.
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.
Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.
Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV.
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses.
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons.
Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice.
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
Identification of an endocytic signal essential for the antiviral action of IFITM3.
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis.
Knockdown of interferon-induced transmembrane protein 3 expression suppresses breast cancer cell growth and colony formation and affects the cell cycle.
IFITM proteins restrict viral membrane hemifusion.
Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
IFITM3 restricts the morbidity and mortality associated with influenza.
The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization.
The IFITM proteins inhibit HIV-1 infection.
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Xiao M, Chen Y, Wang S, Liu S, Rai KR, Chen B, Li F, Li Y, Maarouf M, Chen JL
Journal of virology 2021 Oct 13;95(21):e0027721
Journal of virology 2021 Oct 13;95(21):e0027721
IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization.
Lanz C, Schotsaert M, Magnus C, Karakus U, Hunziker A, Sempere Borau M, Martínez-Romero C, Spieler EE, Günther SC, Moritz E, Hale BG, Trkola A, García-Sastre A, Stertz S
The Journal of experimental medicine 2021 Jun 7;218(6)
The Journal of experimental medicine 2021 Jun 7;218(6)
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F
Nature communications 2021 Jul 28;12(1):4584
Nature communications 2021 Jul 28;12(1):4584
A human apolipoprotein L with detergent-like activity kills intracellular pathogens.
Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Mamiñska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD
Science (New York, N.Y.) 2021 Jul 16;373(6552)
Science (New York, N.Y.) 2021 Jul 16;373(6552)
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Rebendenne A, Valadão ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planès R, Nisole S, Arnaud-Arnould M, Moncorgé O, Goujon C
Journal of virology 2021 Jan 29;
Journal of virology 2021 Jan 29;
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS
The EMBO journal 2021 Feb 1;40(3):e106501
The EMBO journal 2021 Feb 1;40(3):e106501
The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.
Phan QT, Lin J, Solis NV, Eng M, Swidergall M, Wang F, Li S, Gaffen SL, Chou TF, Filler SG
mBio 2021 Dec 21;12(6):e0271621
mBio 2021 Dec 21;12(6):e0271621
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Popova G, Soliman SS, Kim CN, Keefe MG, Hennick KM, Jain S, Li T, Tejera D, Shin D, Chhun BB, McGinnis CS, Speir M, Gartner ZJ, Mehta SB, Haeussler M, Hengen KB, Ransohoff RR, Piao X, Nowakowski TJ
Cell stem cell 2021 Dec 2;28(12):2153-2166.e6
Cell stem cell 2021 Dec 2;28(12):2153-2166.e6
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Winstone H, Lista MJ, Reid AC, Bouton C, Pickering S, Galao RP, Kerridge C, Doores KJ, Swanson CM, Neil SJD
Journal of virology 2021 Apr 12;95(9)
Journal of virology 2021 Apr 12;95(9)
Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Xie J, Bi Y, Xu S, Han Y, Idris A, Zhang H, Li X, Bai J, Zhang Y, Feng R
Virus research 2020 Oct 2;287:198105
Virus research 2020 Oct 2;287:198105
Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
Rai KR, Chen B, Zhao Z, Chen Y, Hu J, Liu S, Maarouf M, Li Y, Xiao M, Liao Y, Chen JL
Cellular microbiology 2020 Nov;22(11):e13242
Cellular microbiology 2020 Nov;22(11):e13242
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
Zhang A, Duan H, Zhao H, Liao H, Du Y, Li L, Jiang D, Wan B, Wu Y, Ji P, Zhou EM, Zhang G
Journal of virology 2020 Nov 23;94(24)
Journal of virology 2020 Nov 23;94(24)
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Wu X, Spence JS, Das T, Yuan X, Chen C, Zhang Y, Li Y, Sun Y, Chandran K, Hang HC, Peng T
Cell chemical biology 2020 May 21;27(5):571-585.e6
Cell chemical biology 2020 May 21;27(5):571-585.e6
Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice.
Sun Q, Lei N, Lu J, Gao RB, Li Z, Liu LQ, Sun Y, Guo JF, Wang DY, Shu YL
Biomedical and environmental sciences : BES 2020 May 20;33(5):295-305
Biomedical and environmental sciences : BES 2020 May 20;33(5):295-305
The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3.
Gobillot TA, Humes D, Sharma A, Kikawa C, Overbaugh J
Viruses 2020 May 2;12(5)
Viruses 2020 May 2;12(5)
Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages.
Lubow J, Virgilio MC, Merlino M, Collins DR, Mashiba M, Peterson BG, Lukic Z, Painter MM, Gomez-Rivera F, Terry V, Zimmerman G, Collins KL
eLife 2020 Mar 2;9
eLife 2020 Mar 2;9
Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
Chemudupati M, Kenney AD, Smith AC, Fillinger RJ, Zhang L, Zani A, Liu SL, Anderson MZ, Sharma A, Yount JS
Journal of virology 2020 Jul 30;94(16)
Journal of virology 2020 Jul 30;94(16)
Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells.
Ali A, Syed SM, Jamaluddin MFB, Colino-Sanguino Y, Gallego-Ortega D, Tanwar PS
Cell reports 2020 Feb 4;30(5):1463-1477.e7
Cell reports 2020 Feb 4;30(5):1463-1477.e7
IFITM3 affects the level of antibody response after influenza vaccination.
Lei N, Li Y, Sun Q, Lu J, Zhou J, Li Z, Liu L, Guo J, Qin K, Wang H, Zhao J, Li C, Sun L, Wang D, Zhao Z, Shu Y
Emerging microbes & infections 2020 Dec;9(1):976-987
Emerging microbes & infections 2020 Dec;9(1):976-987
Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells.
Zhao C, Chen J, Cheng L, Xu K, Yang Y, Su X
Emerging microbes & infections 2020 Dec;9(1):691-706
Emerging microbes & infections 2020 Dec;9(1):691-706
IFITMs of African Green Monkey Can Inhibit Replication of SFTSV but Not MNV In Vitro.
Xing H, Ye L, Fan J, Fu T, Li C, Zhang S, Ren L, Bai J
Viral immunology 2020 Dec;33(10):634-641
Viral immunology 2020 Dec;33(10):634-641
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Sun N, Jiang L, Ye M, Wang Y, Wang G, Wan X, Zhao Y, Wen X, Liang L, Ma S, Liu L, Bu Z, Chen H, Li C
Protein & cell 2020 Dec;11(12):894-914
Protein & cell 2020 Dec;11(12):894-914
Escape of HIV-1 envelope glycoprotein from the restriction of infection by IFITM3.
Drouin A, Migraine J, Durand MA, Moreau A, Burlaud-Gaillard J, Beretta M, Roingeard P, Bouvin-Pley M, Braibant M
Journal of virology 2020 Dec 9;
Journal of virology 2020 Dec 9;
An Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses.
Sánchez-Tacuba L, Feng N, Meade NJ, Mellits KH, Jaïs PH, Yasukawa LL, Resch TK, Jiang B, López S, Ding S, Greenberg HB
Journal of virology 2020 Aug 31;94(18)
Journal of virology 2020 Aug 31;94(18)
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.
Zhao X, Zheng S, Chen D, Zheng M, Li X, Li G, Lin H, Chang J, Zeng H, Guo JT
Journal of virology 2020 Aug 31;94(18)
Journal of virology 2020 Aug 31;94(18)
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Shi G, Kenney AD, Kudryashova E, Zhang L, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS
bioRxiv : the preprint server for biology 2020 Aug 11;
bioRxiv : the preprint server for biology 2020 Aug 11;
Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells.
Hegyesi H, Sándor N, Sáfrány G, Lovas V, Kovács Á, Takács A, Kőhidai L, Turiák L, Kittel Á, Pálóczi K, Bertók L, Buzás EI
Stem cell research & therapy 2019 Oct 29;10(1):313
Stem cell research & therapy 2019 Oct 29;10(1):313
IFITM3 directly engages and shuttles incoming virus particles to lysosomes.
Spence JS, He R, Hoffmann HH, Das T, Thinon E, Rice CM, Peng T, Chandran K, Hang HC
Nature chemical biology 2019 Mar;15(3):259-268
Nature chemical biology 2019 Mar;15(3):259-268
Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro.
Du S, Jiang Y, Xu W, Bai J, Tian M, Wang M, Wang Y, Cao T, Song L, Jiang Y, Chen J, Fu T, Hao P, Li T, Wu S, Ren L, Jin N, Li C
International journal of biological macromolecules 2019 Jun 15;131:925-932
International journal of biological macromolecules 2019 Jun 15;131:925-932
IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells.
Kummer S, Avinoam O, Kräusslich HG
Viruses 2019 Jun 12;11(6)
Viruses 2019 Jun 12;11(6)
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J
PLoS pathogens 2019 Jul;15(7):e1007925
PLoS pathogens 2019 Jul;15(7):e1007925
Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1.
Appourchaux R, Delpeuch M, Zhong L, Burlaud-Gaillard J, Tartour K, Savidis G, Brass A, Etienne L, Roingeard P, Cimarelli A
Journal of virology 2019 Jan 15;93(2)
Journal of virology 2019 Jan 15;93(2)
Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins.
Zani A, Zhang L, McMichael TM, Kenney AD, Chemudupati M, Kwiek JJ, Liu SL, Yount JS
The Journal of biological chemistry 2019 Dec 27;294(52):19844-19851
The Journal of biological chemistry 2019 Dec 27;294(52):19844-19851
Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression.
Wang Q, Su L
mBio 2019 Aug 20;10(4)
mBio 2019 Aug 20;10(4)
The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection.
Li C, Du S, Tian M, Wang Y, Bai J, Tan P, Liu W, Yin R, Wang M, Jiang Y, Li Y, Zhu N, Zhu Y, Li T, Wu S, Jin N, He F
Frontiers in immunology 2018;9:228
Frontiers in immunology 2018;9:228
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
Xu B, Pan Q, Liang C
Journal of virology 2018 Sep 1;92(17)
Journal of virology 2018 Sep 1;92(17)
IFITM3 Restricts Human Metapneumovirus Infection.
McMichael TM, Zhang Y, Kenney AD, Zhang L, Zani A, Lu M, Chemudupati M, Li J, Yount JS
The Journal of infectious diseases 2018 Oct 5;218(10):1582-1591
The Journal of infectious diseases 2018 Oct 5;218(10):1582-1591
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Tsai CY, Chi HC, Chi LM, Yang HY, Tsai MM, Lee KF, Huang HW, Chou LF, Cheng AJ, Yang CW, Wang CS, Lin KH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.
Thinon E, Fernandez JP, Molina H, Hang HC
Journal of proteome research 2018 May 4;17(5):1907-1922
Journal of proteome research 2018 May 4;17(5):1907-1922
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Roesch F, OhAinle M, Emerman M
Retrovirology 2018 Mar 20;15(1):26
Retrovirology 2018 Mar 20;15(1):26
Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus.
Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U
mBio 2018 Jul 24;9(4)
mBio 2018 Jul 24;9(4)
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Petrillo C, Thorne LG, Unali G, Schiroli G, Giordano AMS, Piras F, Cuccovillo I, Petit SJ, Ahsan F, Noursadeghi M, Clare S, Genovese P, Gentner B, Naldini L, Towers GJ, Kajaste-Rudnitski A
Cell stem cell 2018 Dec 6;23(6):820-832.e9
Cell stem cell 2018 Dec 6;23(6):820-832.e9
The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells.
Tammineni ER, Carrillo ED, Soto-Acosta R, Angel-Ambrocio AH, García MC, Bautista-Carbajal P, Del Angel RM, Sánchez JA
Science signaling 2018 Dec 11;11(560)
Science signaling 2018 Dec 11;11(560)
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
Yu J, Liu SL
Viruses 2018 Aug 7;10(8)
Viruses 2018 Aug 7;10(8)
IFITM3 requires an amphipathic helix for antiviral activity.
Chesarino NM, Compton AA, McMichael TM, Kenney AD, Zhang L, Soewarna V, Davis M, Schwartz O, Yount JS
EMBO reports 2017 Oct;18(10):1740-1751
EMBO reports 2017 Oct;18(10):1740-1751
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
Monel B, Compton AA, Bruel T, Amraoui S, Burlaud-Gaillard J, Roy N, Guivel-Benhassine F, Porrot F, Génin P, Meertens L, Sinigaglia L, Jouvenet N, Weil R, Casartelli N, Demangel C, Simon-Lorière E, Moris A, Roingeard P, Amara A, Schwartz O
The EMBO journal 2017 Jun 14;36(12):1653-1668
The EMBO journal 2017 Jun 14;36(12):1653-1668
Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins.
Wrensch F, Hoffmann M, Gärtner S, Nehlmeier I, Winkler M, Pöhlmann S
Journal of virology 2017 Jan 15;91(2)
Journal of virology 2017 Jan 15;91(2)
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B
PLoS pathogens 2017 Dec;13(12):e1006773
PLoS pathogens 2017 Dec;13(12):e1006773
The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.
McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, Yount JS
The Journal of biological chemistry 2017 Dec 29;292(52):21517-21526
The Journal of biological chemistry 2017 Dec 29;292(52):21517-21526
Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.
Sareila O, Hagert C, Kelkka T, Linja M, Xu B, Kihlberg J, Holmdahl R
Antioxidants & redox signaling 2017 Dec 20;27(18):1473-1490
Antioxidants & redox signaling 2017 Dec 20;27(18):1473-1490
Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV.
Wilkins J, Zheng YM, Yu J, Liang C, Liu SL
PloS one 2016;11(6):e0156739
PloS one 2016;11(6):e0156739
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Muñoz-Moreno R, Cuesta-Geijo MÁ, Martínez-Romero C, Barrado-Gil L, Galindo I, García-Sastre A, Alonso C
PloS one 2016;11(4):e0154366
PloS one 2016;11(4):e0154366
The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.
Gorman MJ, Poddar S, Farzan M, Diamond MS
Journal of virology 2016 Sep 15;90(18):8212-25
Journal of virology 2016 Sep 15;90(18):8212-25
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJD
Cell host & microbe 2016 Oct 12;20(4):429-442
Cell host & microbe 2016 Oct 12;20(4):429-442
The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses.
Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS
Journal of virology 2016 Oct 1;90(19):8780-94
Journal of virology 2016 Oct 1;90(19):8780-94
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL
Research in veterinary science 2016 Feb;104:40-9
Research in veterinary science 2016 Feb;104:40-9
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Yu J, Li M, Wilkins J, Ding S, Swartz TH, Esposito AM, Zheng YM, Freed EO, Liang C, Chen BK, Liu SL
Cell reports 2015 Oct 6;13(1):145-156
Cell reports 2015 Oct 6;13(1):145-156
Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.
Koyama N, Hakura A, Toritsuka N, Sonoda J, Seki Y, Tohyama O, Asakura S, Nakano-Ito K, Hosokawa S
Chemico-biological interactions 2015 Oct 5;240:164-70
Chemico-biological interactions 2015 Oct 5;240:164-70
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.
Zhu X, He Z, Yuan J, Wen W, Huang X, Hu Y, Lin C, Pan J, Li R, Deng H, Liao S, Zhou R, Wu J, Li J, Li M
Cellular microbiology 2015 Jan;17(1):105-18
Cellular microbiology 2015 Jan;17(1):105-18
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
Qian J, Le Duff Y, Wang Y, Pan Q, Ding S, Zheng YM, Liu SL, Liang C
Virology 2015 Jan 1;474:10-8
Virology 2015 Jan 1;474:10-8
Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons.
Chen Z, Luo G, Wang Q, Wang S, Chi X, Huang Y, Wei H, Wu B, Huang S, Chen JL
Veterinary microbiology 2015 Feb 25;175(2-4):232-43
Veterinary microbiology 2015 Feb 25;175(2-4):232-43
Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice.
Yu M, Qi W, Huang Z, Zhang K, Ye J, Liu R, Wang H, Ma Y, Liao M, Ning Z
Medical microbiology and immunology 2015 Aug;204(4):505-14
Medical microbiology and immunology 2015 Aug;204(4):505-14
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Chesarino NM, McMichael TM, Yount JS
PLoS pathogens 2015 Aug;11(8):e1005095
PLoS pathogens 2015 Aug;11(8):e1005095
T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.
Ariotti S, Hogenbirk MA, Dijkgraaf FE, Visser LL, Hoekstra ME, Song JY, Jacobs H, Haanen JB, Schumacher TN
Science (New York, N.Y.) 2014 Oct 3;346(6205):101-5
Science (New York, N.Y.) 2014 Oct 3;346(6205):101-5
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Tartour K, Appourchaux R, Gaillard J, Nguyen XN, Durand S, Turpin J, Beaumont E, Roch E, Berger G, Mahieux R, Brand D, Roingeard P, Cimarelli A
Retrovirology 2014 Nov 25;11:103
Retrovirology 2014 Nov 25;11:103
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block TM, Guo JT
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
Identification of an endocytic signal essential for the antiviral action of IFITM3.
Jia R, Xu F, Qian J, Yao Y, Miao C, Zheng YM, Liu SL, Guo F, Geng Y, Qiao W, Liang C
Cellular microbiology 2014 Jul;16(7):1080-93
Cellular microbiology 2014 Jul;16(7):1080-93
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Compton AA, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, Liang C, Casartelli N, Schwartz O
Cell host & microbe 2014 Dec 10;16(6):736-47
Cell host & microbe 2014 Dec 10;16(6):736-47
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Wang S, Chi X, Wei H, Chen Y, Chen Z, Huang S, Chen JL
Journal of virology 2014 Aug;88(15):8375-85
Journal of virology 2014 Aug;88(15):8375-85
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S
Journal of virology 2013 Jun;87(11):6150-60
Journal of virology 2013 Jun;87(11):6150-60
Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis.
Zhang LK, Chai F, Li HY, Xiao G, Guo L
Journal of proteome research 2013 Jun 7;12(6):2666-78
Journal of proteome research 2013 Jun 7;12(6):2666-78
Knockdown of interferon-induced transmembrane protein 3 expression suppresses breast cancer cell growth and colony formation and affects the cell cycle.
Yang M, Gao H, Chen P, Jia J, Wu S
Oncology reports 2013 Jul;30(1):171-8
Oncology reports 2013 Jul;30(1):171-8
IFITM proteins restrict viral membrane hemifusion.
Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL
PLoS pathogens 2013 Jan;9(1):e1003124
PLoS pathogens 2013 Jan;9(1):e1003124
Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.
Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A
The Journal of biological chemistry 2013 Dec 6;288(49):35093-103
The Journal of biological chemistry 2013 Dec 6;288(49):35093-103
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
Mudhasani R, Tran JP, Retterer C, Radoshitzky SR, Kota KP, Altamura LA, Smith JM, Packard BZ, Kuhn JH, Costantino J, Garrison AR, Schmaljohn CS, Huang IC, Farzan M, Bavari S
Journal of virology 2013 Aug;87(15):8451-64
Journal of virology 2013 Aug;87(15):8451-64
IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators., MOSAIC Investigators., Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P
Nature 2012 Mar 25;484(7395):519-23
Nature 2012 Mar 25;484(7395):519-23
The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization.
Jia R, Pan Q, Ding S, Rong L, Liu SL, Geng Y, Qiao W, Liang C
Journal of virology 2012 Dec;86(24):13697-707
Journal of virology 2012 Dec;86(24):13697-707
The IFITM proteins inhibit HIV-1 infection.
Lu J, Pan Q, Rong L, He W, Liu SL, Liang C
Journal of virology 2011 Mar;85(5):2126-37
Journal of virology 2011 Mar;85(5):2126-37
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.
Weidner JM, Jiang D, Pan XB, Chang J, Block TM, Guo JT
Journal of virology 2010 Dec;84(24):12646-57
Journal of virology 2010 Dec;84(24):12646-57
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, Block TM, Guo JT
Journal of virology 2010 Aug;84(16):8332-41
Journal of virology 2010 Aug;84(16):8332-41
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11714-1-AP(IFITM3 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IFITM3 (IP:11714-1-AP, 3ug; Detection:11714-1-AP 1:1500) with HeLa cells lysate 2400ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFITM3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFITM3. This antibody recognizes human,mouse,rat antigen. The IFITM3 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.