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ALDOB
Aldolase, fructose-bisphosphate BFructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Top validated antibodies |
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| Proteintech Group |  18065-1-AP |
13 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | PA5-30218 |
1 references | Polyclonal |
WB
ICC
IHC
OA
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| NSJ Bioreagents | RQ5569 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A03893-2 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX101363 |
1 references | Polyclonal |
WB
ICC
IHC
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