BS6516

antibody from Bioworld Technology, Inc
Targeting: NR0B1 AHC, AHCH, DAX1, DSS
Provider product page for BS6516
Western blot
Immunohistochemistry

Antibody data

Product number
BS6516 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NR0B1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NR0B1.
Description
AHC has been mapped to chromosome Xp21 at the same or close to an X-linked locus involved in sex determination, DSS (for dosage-sensitive sex reversal). The gene corresponding to DSS and AHC (designated DAX-1 for DSS-AHC critical region on the X chromosome, gene 1) has been cloned and shown to be deleted in AHC deletion patients and mutated in AHC non-deletion patients. The carboxy terminal 250 amino acids of the DAX-1-encoded protein, DAX-1, exhibits approximately 50% continuous similarity to the ligand-binding domain of the members of the nuclear hormone receptor superfamily while the amino terminal domain contains a putative DNA-binding motif. DAX-1 binds to retinoic acid responsive elements and down regulates retinoic acid receptor-mediated transcriptional activation.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NR0B1 protein structure - BS6516 shown in red.