BS6051

antibody from Bioworld Technology, Inc
Targeting: VHL VHL1
Provider product page for BS6051
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6051 - Provider product page
Provider
Bioworld Technology, Inc
Product name
VHL polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human VHL.
Description
Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
VHL protein structure - BS6051 shown in red.