BS8198

antibody from Bioworld Technology, Inc
Targeting: SSRP1 FACT80
Provider product page for BS8198
Western blot
Immunohistochemistry

Antibody data

Product number
BS8198 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SSRP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SSRP1.
Description
Expression of protein-coding genes requires the association of specific transcription factors, RNA polymerase and various accessory factors (1). These accessory factors are distinguished as either histone acetyltransferases or ATP-dependent chromatin-remodeling enzymes, which include FACT (for facilitates chromatin transcription), and they facilitate transcription initiation on DNA packaged into chromatin. FACT is a chromatin-specific elongation factor required for transcription of chromatin templates, and it specifically interacts with nucleosomes and histone H2A/H2B dimers, to promote nucleosome disassembly upon transcription. FACT represents a complex between SPT16, a homologue of the Saccharomyces cerevisiae Spt16/Cdc68 protein, and the high-mobility group (HMG)-1-like protein structure-specific recognition protein-1 (SSRP-1). Similar to other (HMG) domain containing proteins, which are characterized by their ability to bend target DNAs, SSRP1 and the murine ortholog T160, physically interact with serum response factors (SRF) and function as positive co-regulatory proteins involved in modulating SRF-dependent gene expression .
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SSRP1 protein structure - BS8198 shown in red.