Ab088039

antibody from Aladdin Scientific Corporation

Targeting: ALDH1A1 ALDH1, PUMB1, RALDH1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab088039

Provider

Aladdin Scientific Corporation

Product name

ALDH1A1 Mouse mAb

Antibody type

Monoclonal

Description

Application:WB: 1/500 - 1/2000. Predicted molecular weight: 55 kDa. IHC: 1/200 - 1/1000 ELISA: 1/10000Protein FunctionBinds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum; this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA: 7-128


Isotype

IgG

Antibody clone number

5A11

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.