OXGR1

This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Description

Oxoglutarate receptor 1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

13 (96985719 - 96994730)

Ensembl ID

ENSG00000165621  (ver. 103.38)

Orthologs

Mouse Oxgr1: ENSMUSG00000044819

UniProt

Q96P68

neXtProt

NX_Q96P68

Human splice variants
Mouse splice variants

Protein structure