BS7755

antibody from Bioworld Technology, Inc
Targeting: APTX AOA, AOA1, AXA1, EAOH, EOAHA, FLJ20157
Provider product page for BS7755
Western blot
Immunohistochemistry

Antibody data

Product number
BS7755 - Provider product page
Provider
Bioworld Technology, Inc
Product name
APTX polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human APTX.
Description
Aprataxin is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. Aprataxin is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. Aprataxin contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes. These mutations either target the HIT domain or truncate the protein N-terminal to a zinc finger.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
APTX protein structure - BS7755 shown in red.