HOXD12

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]

Description

Homeobox D12

Tissue specificity

Tissue enhanced (intestine, seminal vesicle)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

2 (176099795 - 176102489)

Ensembl ID

ENSG00000170178  (ver. 103.38)

Orthologs

Mouse Hoxd12: ENSMUSG00000001823

UniProt

P35452

neXtProt

NX_P35452

Human splice variants
Mouse splice variants

Protein structure