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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
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- Product number
- NB100-493 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-493, RRID:AB_10000910
- Product name
- Rabbit Polyclonal PINK1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. PINK1 Antibody is expected recognize isoform 1 and basted on a homology blast, will not recognized isoform 2.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1.
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons.
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Kim SJ, Cheresh P, Jablonski RP, Rachek L, Yeldandi A, Piseaux-Aillon R, Ciesielski MJ, Ridge K, Gottardi C, Lam AP, Pardo A, Selman M, Natarajan V, Kamp DW
American journal of physiology. Lung cellular and molecular physiology 2020 May 1;318(5):L1084-L1096
American journal of physiology. Lung cellular and molecular physiology 2020 May 1;318(5):L1084-L1096
Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1.
Hwang SH, Kim MC, Ji S, Yang Y, Jeong Y, Kim Y
Cancer science 2019 Apr;110(4):1256-1267
Cancer science 2019 Apr;110(4):1256-1267
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons.
Amadoro G, Corsetti V, Florenzano F, Atlante A, Ciotti MT, Mongiardi MP, Bussani R, Nicolin V, Nori SL, Campanella M, Calissano P
Neurobiology of disease 2014 Feb;62:489-507
Neurobiology of disease 2014 Feb;62:489-507
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.
Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H
Journal of neuropathology and experimental neurology 2011 Aug;70(8):686-97
Journal of neuropathology and experimental neurology 2011 Aug;70(8):686-97
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF
The Journal of biological chemistry 2009 Aug 21;284(34):22938-51
The Journal of biological chemistry 2009 Aug 21;284(34):22938-51
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: PINK1 Antibody [NB100-493] - Detection of murine PINK1 using NB100-493. Lane 1: molecular weight marker. Lane 2. MES cell Mitochondria (20 ug) with a band at the observed molecular weight of 63 kDa. Lane 3. MES cytosol (20 ug). Lane 4. MES nuclear (20 ug) as negative control.Lane 5. Purified human cytochrome C (0.1 ug) as PINK1 negative control.
