NUDT5

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Description

Nudix hydrolase 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Centrosome

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (12165330 - 12196144)

Ensembl ID

ENSG00000165609  (ver. 103.38)

Orthologs

Mouse Nudt5: ENSMUSG00000025817

UniProt

Q9UKK9

neXtProt

NX_Q9UKK9

Human splice variants
Mouse splice variants

Protein structure