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- Antibody Data
- Antigen structure
- References [35]
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- Immunohistochemistry [1]
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- Product number
- 10753-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10753-1-AP, RRID:AB_2204547
- Product name
- TIMP1 antibody
- Antibody type
- Polyclonal
- Description
- TIMP1 antibody (Cat. #10753-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model.
CEACAM1 Inhibited IκB-α/NF-κB Signal Pathway Via Targeting MMP-9/TIMP-1 Axis in Diabetic Atherosclerosis.
Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats.
Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin.
Lanthanum Chloride Impairs the Blood-Brain Barrier Integrity by Reduction of Junctional Proteins and Upregulation of MMP-9 in Rats.
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation.
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
MiR-210-3p inhibits the tumor growth and metastasis of bladder cancer via targeting fibroblast growth factor receptor-like 1.
FOXO transcription factors protect against the diet-induced fatty liver disease.
In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis.
Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells.
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.
IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.
Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis.
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat-fed ApoE-knockout mice.
Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion.
Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Potent effects of dioscin against liver fibrosis.
A panel of overexpressed proteins for prognosis in esophageal squamous cell carcinoma.
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
Effects of reduced β2-glycoprotein I on the expression of aortic matrix metalloproteinases and tissue inhibitor matrix metalloproteinases in diabetic mice.
C-Kit/c-Kit ligand interaction of bone marrow endothelial progenitor cells is influenced in a cigarette smoke extract-induced emphysema model.
Ji J, Yu Q, Dai W, Wu L, Feng J, Zheng Y, Li Y, Guo C
PPAR research 2021;2021:6651839
PPAR research 2021;2021:6651839
Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model.
Lin S, Jin S, Zhou F, Hu Y, Zhang M
Experimental and therapeutic medicine 2021 Oct;22(4):1125
Experimental and therapeutic medicine 2021 Oct;22(4):1125
CEACAM1 Inhibited IκB-α/NF-κB Signal Pathway Via Targeting MMP-9/TIMP-1 Axis in Diabetic Atherosclerosis.
Yu J, Sun G, Chen Y, Li L, Wang H, Tu D, Li L, Meng Z, Wang Y
Journal of cardiovascular pharmacology 2020 Sep;76(3):329-336
Journal of cardiovascular pharmacology 2020 Sep;76(3):329-336
Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.
Udi S, Hinden L, Ahmad M, Drori A, Iyer MR, Cinar R, Herman-Edelstein M, Tam J
British journal of pharmacology 2020 Jan;177(1):110-127
British journal of pharmacology 2020 Jan;177(1):110-127
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats.
Yang P, Tian YM, Deng WX, Cai X, Liu WH, Li L, Huang HY
Experimental and therapeutic medicine 2019 Oct;18(4):2805-2812
Experimental and therapeutic medicine 2019 Oct;18(4):2805-2812
Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin.
Liu T, Xu L, Wang C, Chen K, Xia Y, Li J, Li S, Wu L, Feng J, Xu S, Wang W, Lu X, Fan X, Mo W, Zhou Y, Zhao Y, Guo C
Journal of gastroenterology and hepatology 2019 Jan;34(1):263-276
Journal of gastroenterology and hepatology 2019 Jan;34(1):263-276
Lanthanum Chloride Impairs the Blood-Brain Barrier Integrity by Reduction of Junctional Proteins and Upregulation of MMP-9 in Rats.
Wu J, Yang J, Lu X, Jin C, Wu S, Zhang L, Hu X, Ma H, Cai Y
Biological trace element research 2019 Feb;187(2):482-491
Biological trace element research 2019 Feb;187(2):482-491
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C
Drug design, development and therapy 2018;12:1837-1853
Drug design, development and therapy 2018;12:1837-1853
Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation.
Wei SD, Cao D, Xu XS, Bai H, Wu H, Wang MH
Molecular medicine reports 2018 May;17(5):6909-6913
Molecular medicine reports 2018 May;17(5):6909-6913
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Zhang J, Yang A, Wu Y, Guan W, Xiong B, Peng X, Wei X, Chen C, Liu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Zhang M, Hu X, Li S, Lu C, Li J, Zong Y, Qi W, Yang H
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
MiR-210-3p inhibits the tumor growth and metastasis of bladder cancer via targeting fibroblast growth factor receptor-like 1.
Yang X, Shi L, Yi C, Yang Y, Chang L, Song D
American journal of cancer research 2017;7(8):1738-1753
American journal of cancer research 2017;7(8):1738-1753
FOXO transcription factors protect against the diet-induced fatty liver disease.
Pan X, Zhang Y, Kim HG, Liangpunsakul S, Dong XC
Scientific reports 2017 Mar 16;7:44597
Scientific reports 2017 Mar 16;7:44597
In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis.
Yang W, Zhao J, Wang Y, Xu H, Wu Z, Hu Y, Jiang K, Shen P, Ma C, Guan Z, Zhang Y, Ma J, Shang N, Yan G, Wang Z, Dai G
Toxicology and applied pharmacology 2017 Jul 15;327:1-12
Toxicology and applied pharmacology 2017 Jul 15;327:1-12
Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
Cui X, Dang S, Wang Y, Chen Y, Zhou J, Shen C, Kuang Y, Fei J, Lu L, Wang Z
Toxicology letters 2017 Jan 4;265:17-22
Toxicology letters 2017 Jan 4;265:17-22
Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway.
Neoh CA, Wu WT, Dai GF, Su JH, Liu CI, Su TR, Wu YJ
Molecules (Basel, Switzerland) 2017 Dec 27;23(1)
Molecules (Basel, Switzerland) 2017 Dec 27;23(1)
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific reports 2017 Aug 24;7(1):9289
Scientific reports 2017 Aug 24;7(1):9289
Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells.
Cheng TC, Din ZH, Su JH, Wu YJ, Liu CI
Marine drugs 2017 Aug 2;15(8)
Marine drugs 2017 Aug 2;15(8)
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.
Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C
Drug design, development and therapy 2016;10:619-30
Drug design, development and therapy 2016;10:619-30
IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.
Dong Z, Zhao X, Tai W, Lei W, Wang Y, Li Z, Zhang T
Life sciences 2016 Feb 1;146:24-33
Life sciences 2016 Feb 1;146:24-33
Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis.
Yang Q, Cui J, Wang P, Du X, Wang W, Zhang T, Chen Y
European journal of pharmacology 2016 Aug 5;784:22-32
European journal of pharmacology 2016 Aug 5;784:22-32
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Lu L, Wang J, Lu H, Zhang G, Liu Y, Wang J, Zhang Y, Shang H, Ji H, Chen X, Duan Y, Li Y
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Mao Y, Zhang S, Yu F, Li H, Guo C, Fan X
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat-fed ApoE-knockout mice.
Zhou M, Xu H, Liu W, Liu H
Experimental and therapeutic medicine 2015 Oct;10(4):1265-1270
Experimental and therapeutic medicine 2015 Oct;10(4):1265-1270
Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion.
Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, Li Y, Kong Y
Cell and tissue research 2015 Nov;362(2):421-30
Cell and tissue research 2015 Nov;362(2):421-30
Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.
Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML
International journal of biological macromolecules 2015 Mar;74:476-82
International journal of biological macromolecules 2015 Mar;74:476-82
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Wu YJ, Neoh CA, Tsao CY, Su JH, Li HH
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
A panel of overexpressed proteins for prognosis in esophageal squamous cell carcinoma.
Shang L, Liu HJ, Hao JJ, Jiang YY, Shi F, Zhang Y, Cai Y, Xu X, Jia XM, Zhan QM, Wang MR
PloS one 2014;9(10):e111045
PloS one 2014;9(10):e111045
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
Shen M, Chen K, Lu J, Cheng P, Xu L, Dai W, Wang F, He L, Zhang Y, Chengfen W, Li J, Yang J, Zhu R, Zhang H, Zheng Y, Zhou Y, Guo C
Mediators of inflammation 2014;2014:954502
Mediators of inflammation 2014;2014:954502
11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
Lin JJ, Su JH, Tsai CC, Chen YJ, Liao MH, Wu YJ
Marine drugs 2014 Sep 12;12(9):4783-98
Marine drugs 2014 Sep 12;12(9):4783-98
Effects of reduced β2-glycoprotein I on the expression of aortic matrix metalloproteinases and tissue inhibitor matrix metalloproteinases in diabetic mice.
Xu J, Wang P, Wang T, Wang M, Chen S, Yu P, Yu D
BMC cardiovascular disorders 2014 Sep 10;14:114
BMC cardiovascular disorders 2014 Sep 10;14:114
C-Kit/c-Kit ligand interaction of bone marrow endothelial progenitor cells is influenced in a cigarette smoke extract-induced emphysema model.
He S, He Z, Chen Y, Ye J, Zong D, Zhang Y, Chen P
Experimental lung research 2013 Aug;39(6):258-67
Experimental lung research 2013 Aug;39(6):258-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TIMP-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TIMP-1. This antibody recognizes human, mouse antigen. The TIMP-1 antibody has been validated for the following applications: ELISA, IHC analysis.
