Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [3]
- Immunohistochemistry [1]
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- AF970 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal TIMP-1 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human TIMP-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse TIMP-1 and recombinant rat TIMP-1 is observed and less than 1% cross-reactivity with recombinant human (rh) TIMP-2, rhTIMP-3, and rhTIMP-4 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.
Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study.
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis.
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Fibroblast-conditioned media promote human sarcoma cell invasion.
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P
Cell reports 2019 Sep 24;28(13):3329-3337.e5
Cell reports 2019 Sep 24;28(13):3329-3337.e5
Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
Ding X, Yang DR, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C
Molecular cancer 2015 Jan 27;14(1):16
Molecular cancer 2015 Jan 27;14(1):16
Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study.
Thorsen SB, Christensen SL, Würtz SO, Lundberg M, Nielsen BS, Vinther L, Knowles M, Gee N, Fredriksson S, Møller S, Brünner N, Schrohl AS, Stenvang J
BMC cancer 2013 Dec 13;13:598
BMC cancer 2013 Dec 13;13:598
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E
Nature medicine 2011 Oct 30;17(11):1498-503
Nature medicine 2011 Oct 30;17(11):1498-503
Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis.
Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, Chang KJ, Lee EY, Lee WH
PloS one 2011 Jan 13;6(1):e15313
PloS one 2011 Jan 13;6(1):e15313
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
European journal of haematology 2010 Mar;84(3):239-51
European journal of haematology 2010 Mar;84(3):239-51
Fibroblast-conditioned media promote human sarcoma cell invasion.
Bittner JG 4th, Wilson M, Shah MB, Albo D, Feig BW, Wang TN
Surgery 2009 Jan;145(1):42-7
Surgery 2009 Jan;145(1):42-7
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.
Saunders WB, Bohnsack BL, Faske JB, Anthis NJ, Bayless KJ, Hirschi KK, Davis GE
The Journal of cell biology 2006 Oct 9;175(1):179-91
The Journal of cell biology 2006 Oct 9;175(1):179-91
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human TIMP-1 by Western Blot. Detection of Human TIMP-1 by Western Blot.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human TIMP-1 by Western Blot. Detection of Human TIMP-1 by Western Blot.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human TIMP-1 by Simple WesternTM. Detection of Human TIMP-1 by Simple WesternTM.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- TIMP-1 in Human Colon Cancer Tissue. TIMP-1 in Human Colon Cancer Tissue.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Neutralization of TIMP-1 Activity by Human TIMP-1 Antibody. Neutralization of TIMP-1 Activity by Human TIMP-1 Antibody.