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- Antibody Data
- Antigen structure
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- Western blot [1]
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- Product number
- 635302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#635302, RRID:AB_2204557
- Product name
- Purified anti-TIMP-1
- Antibody type
- Monoclonal
- Antigen
- Ovalbumin-conjugated synthetic Peptide FQALGDAADIR
- Description
- TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD. TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels TIMP-1 protein has been found in several types of cancers including breast cancer and this increase associated with a poor patient prognosis. TIMP-1 has also been implicated in the inhibition of apoptosis, promotion of growth, and process of angiogenesis. TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). Clone F31P2A5 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human and monkey TIMP-1.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store undiluted at 4°C.
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- Experimental details
- Western blot analysis of recombinant human TIMP-1 protein using anti-TIMP-1, clone F31P2A5.
- Conjugate
- Unconjugated
