Tissue expression
Cell line expression
Protein structure
EMP2
Epithelial membrane protein 2XMP
This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]
Top validated antibodies |
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Atlas Antibodies | HPA014711 | 3 references | Polyclonal |
WB
ICC
IHC
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Novus Biologicals | NBP1-86847 | 3 references | Polyclonal |
WB
ICC
IHC
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LSBio | LS-C31949 | Polyclonal |
WB
IHC |
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Biorbyt | orb100917 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-53220 | Polyclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider