ADAMTS6

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 6

Tissue specificity

Tissue enhanced (placenta)

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

5 (65148738 - 65481920)

Ensembl ID

ENSG00000049192  (ver. 103.38)

Orthologs

Mouse Adamts6: ENSMUSG00000046169

UniProt

Q9UKP5

neXtProt

NX_Q9UKP5

Human splice variants
Mouse splice variants

Protein structure