Antibody data

Product number
BS60817 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PTMA polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human PTMA.
Description
ProthymosinÏ«(PTÏ«) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cell leukemia virus-infected T cells andmyeloma cells. The human PTÏ« genemaps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTÏ« is a chromatin-remodeling protein that wasinitiallythought to mediate T lymphocyte maturation, butsubsequently has been shown to be involved in cellcycle progression, proliferation and cell differentiation. PTÏ« isthought to be transported into the nucleus bythe karyopherin ÉÇ1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H4. Also, PTÏ« is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin Ï«-phosphorylating kinase (PTÏ«K) in amitogen activating pathway. The amino terminus of PTÏ« iscleaved to produce a secreted, biologically active peptide thymosin Ï«1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis, or as an immunoen hancer of vaccinesin immunocompromised individuals.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PTMA protein structure - BS60817 shown in red.