Ab130656

antibody from Aladdin Scientific Corporation

Targeting: TEAD1 AA, TCF13, TEF-1

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab130656

Provider

Aladdin Scientific Corporation

Product name

Recombinant TEF1/TEAD-1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human TEF1/TEAD-1 Antibody, Recombinant (R05-1H3), could be used for WB and so on.ApplicationWB: 1/500-1/1000Protein FunctionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Reactivity

Human, Rat, Hamster

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 411-426


Antibody clone number

R05-1H3

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.