BS2869

antibody from Bioworld Technology, Inc
Targeting: CRH CRF, CRH1
Provider product page for BS2869
Western blot
Immunohistochemistry

Antibody data

Product number
BS2869 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CRF (R153) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 121-170 of Human CRF.
Description
Individuals suffering from Alzheimer£ªs disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of ¡ùfree CRF¡ì available to bind CRFRs. Two CRFRs, designated CRF-RI and CFR-RII, have been described and exhibit distinct brain localizations.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CRH protein structure - BS2869 shown in red.