347301

antibody from BioLegend

Targeting: CSF1R C-FMS, CD115, CSFR, FMS

Immunoprecipitation (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

347301

Provider

BioLegend

Product name

Purified anti-human CD115 (CSF-1R)

Antibody type

Monoclonal

Antigen

c-fms transduced Kirsten strain murine sarcoma virus transformed NRK cells

Description

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homo-dimerization in addition to phosphorylation and ubiquitinylation of intracellular residues. The natural ligands of CD115 include M-CSF and IL-34. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, plasmacytoid and conventional dendritic cells, and osteoclasts.

Reactivity

Human

Host

Rat

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4 °C.