Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 347302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#347302, RRID:AB_2085375
- Product name
- Purified anti-human CD115 (CSF-1R)
- Antibody type
- Monoclonal
- Antigen
- c-fms transduced Kirsten strain murine sarcoma virus transformed NRK cells
- Description
- CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homo-dimerization in addition to phosphorylation and ubiquitinylation of intracellular residues. The natural ligands of CD115 include M-CSF and IL-34. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, plasmacytoid and conventional dendritic cells, and osteoclasts.
- Reactivity
- Human
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes were stained with purified CD115 (clone 9-4D2-1E4) (filled histogram) or rat IgG1, κ isotype control (open histogram), followed by biotinylated anti-rat IgG and Sav-PE.
- Conjugate
- Unconjugated