Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AB-206-NA - Provider product page
- Provider
- R&D Systems
- Product name
- Human IL-6 Antibody
- Antibody type
- Polyclonal
- Description
- Protein A or G purified. Detects human IL-6 in direct ELISAs and Western blots. In these formats, less than 5% cross-reactivity with recombinant mouse IL-6, recombinant bovine IL-6, recombinant porcine IL-6, recombinant equine IL-6, recombinant feline IL-6, recombinant rat IL-6, recombinant cotton rat IL-6, recombinant rabbit IL-6, and recombinant viral IL-6 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P05231
- Isotype
- IgG
- Vial size
- 1 mg
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth.
Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells.
McLean K, Tan L, Bolland DE, Coffman LG, Peterson LF, Talpaz M, Neamati N, Buckanovich RJ
Oncogene 2019 Feb;38(9):1576-1584
Oncogene 2019 Feb;38(9):1576-1584
Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Zhan Z, Xie X, Cao H, Zhou X, Zhang XD, Fan H, Liu Z
Autophagy 2014 Feb;10(2):257-68
Autophagy 2014 Feb;10(2):257-68
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E
Nature medicine 2011 Oct 30;17(11):1498-503
Nature medicine 2011 Oct 30;17(11):1498-503
CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells.
Solanilla A, Déchanet J, El Andaloussi A, Dupouy M, Godard F, Chabrol J, Charbord P, Reiffers J, Nurden AT, Weksler B, Moreau JF, Ripoche J
Blood 2000 Jun 15;95(12):3758-64
Blood 2000 Jun 15;95(12):3758-64
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by IL-6 and Neutralization by Human IL-6 Antibody. Recombinant Human IL-6 (Catalog # 206-IL) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-6 (2.5 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-6 Polyclonal Antibody (Catalog # AB-206-NA). The ND50 is typically 0.05-0.15 µg/mL.