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LearnABIN151435
antibody from antibodies-online
Targeting: SMN1
BCD541, GEMIN1, SMA, SMA@, SMA1, SMA2, SMA3, SMNT, TDRD16A
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151435 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Simian, Xenopus
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 2B1
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22.
Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy.
Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish.
Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells.
miRNP:mRNA association in polyribosomes in a human neuronal cell line.
snRNAs contain specific SMN-binding domains that are essential for snRNP assembly.
The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway.
Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.
The SMN complex, an assemblyosome of ribonucleoproteins.
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.
SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.
Survival motor neuron protein modulates neuron-specific apoptosis.
Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.
A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems.
Survival motor neuron (SMN) protein in rat is expressed as different molecular forms and is developmentally regulated.
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing.
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.
A novel nuclear structure containing the survival of motor neurons protein.
Kobayashi M, Chandrasekhar A, Cheng C, Martinez JA, Ng H, de la Hoz C, Zochodne DW
Disease models & mechanisms 2017 Mar 1;10(3):215-224
Disease models & mechanisms 2017 Mar 1;10(3):215-224
Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy.
Chen HY, Lin YN, Chen WC, Wang SJ, Chen CJ, Chen YH
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2017 Aug;37(6):757-765
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2017 Aug;37(6):757-765
Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish.
Spiró Z, Koh A, Tay S, See K, Winkler C
Scientific reports 2016 Jun 7;6:27470
Scientific reports 2016 Jun 7;6:27470
Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells.
Kassim SH, Jordan J, Schreiter J, Adhikarakunnathu S, Baribaud F, San Mateo L
Cellular immunology 2013 Jul-Aug;284(1-2):119-28
Cellular immunology 2013 Jul-Aug;284(1-2):119-28
miRNP:mRNA association in polyribosomes in a human neuronal cell line.
Nelson PT, Hatzigeorgiou AG, Mourelatos Z
RNA (New York, N.Y.) 2004 Mar;10(3):387-94
RNA (New York, N.Y.) 2004 Mar;10(3):387-94
snRNAs contain specific SMN-binding domains that are essential for snRNP assembly.
Yong J, Golembe TJ, Battle DJ, Pellizzoni L, Dreyfuss G
Molecular and cellular biology 2004 Apr;24(7):2747-56
Molecular and cellular biology 2004 Apr;24(7):2747-56
The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway.
Massenet S, Pellizzoni L, Paushkin S, Mattaj IW, Dreyfuss G
Molecular and cellular biology 2002 Sep;22(18):6533-41
Molecular and cellular biology 2002 Sep;22(18):6533-41
Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G
The Journal of biological chemistry 2002 Mar 1;277(9):7540-5
The Journal of biological chemistry 2002 Mar 1;277(9):7540-5
The SMN complex, an assemblyosome of ribonucleoproteins.
Paushkin S, Gubitz AK, Massenet S, Dreyfuss G
Current opinion in cell biology 2002 Jun;14(3):305-12
Current opinion in cell biology 2002 Jun;14(3):305-12
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G
The Journal of biological chemistry 2002 Feb 15;277(7):5631-6
The Journal of biological chemistry 2002 Feb 15;277(7):5631-6
SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.
Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G
Molecular cell 2001 May;7(5):1111-7
Molecular cell 2001 May;7(5):1111-7
Survival motor neuron protein modulates neuron-specific apoptosis.
Kerr DA, Nery JP, Traystman RJ, Chau BN, Hardwick JM
Proceedings of the National Academy of Sciences of the United States of America 2000 Nov 21;97(24):13312-7
Proceedings of the National Academy of Sciences of the United States of America 2000 Nov 21;97(24):13312-7
Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G
The Journal of cell biology 2000 Mar 20;148(6):1177-86
The Journal of cell biology 2000 Mar 20;148(6):1177-86
A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems.
Giesemann T, Rathke-Hartlieb S, Rothkegel M, Bartsch JW, Buchmeier S, Jockusch BM, Jockusch H
The Journal of biological chemistry 1999 Dec 31;274(53):37908-14
The Journal of biological chemistry 1999 Dec 31;274(53):37908-14
Survival motor neuron (SMN) protein in rat is expressed as different molecular forms and is developmentally regulated.
La Bella V, Cisterni C, Salaün D, Pettmann B
The European journal of neuroscience 1998 Sep;10(9):2913-23
The European journal of neuroscience 1998 Sep;10(9):2913-23
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing.
Pellizzoni L, Kataoka N, Charroux B, Dreyfuss G
Cell 1998 Nov 25;95(5):615-24
Cell 1998 Nov 25;95(5):615-24
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.
Fischer U, Liu Q, Dreyfuss G
Cell 1997 Sep 19;90(6):1023-9
Cell 1997 Sep 19;90(6):1023-9
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.
Liu Q, Fischer U, Wang F, Dreyfuss G
Cell 1997 Sep 19;90(6):1013-21
Cell 1997 Sep 19;90(6):1013-21
A novel nuclear structure containing the survival of motor neurons protein.
Liu Q, Dreyfuss G
The EMBO journal 1996 Jul 15;15(14):3555-65
The EMBO journal 1996 Jul 15;15(14):3555-65
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Supportive validation
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- antibodies-online (provider)
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- ICC
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
