10-10020-25

antibody from ABEOMICS Inc.
Targeting: CD209 CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Provider product page for 10-10020-25

Antibody data

Product number
10-10020-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Dc-Sign/CD 209 Antibody
Antibody type
Monoclonal
Description
Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A recombinant protein fragment of D
C-Sign protein was used as the immu
nogen for this antibody.
Isotype
IgG
Antibody clone number
ABM47B7
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
CD209 protein structure - 10-10020-25 shown in red.