330102

antibody from BioLegend
Targeting: CD209 CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Provider product page for 330102
Western blot
Immunocytochemistry
Flow cytometry

Antibody data

Product number
330102 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#330102, RRID:AB_1134253
Product name
Purified anti-human CD209 (DC-SIGN)
Antibody type
Monoclonal
Antigen
Extracellular domain of human DC-SIGN
Description
CD209, known as Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), is a 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family. CD209 is expressed on myeloid dendritic cells, placental macrophages, liver and placental endothelial cells. CD209 binds to ICAM-3 (CD50), ICAM-2 (CD102), and Butyrophilin (BTN2A1), and mediates dendritic cell migration and T cell proliferation. Importantly, CD209 is a receptor of HIV-1 and some other viruses (such as West Nile virus, hepatitis C virus, etc), and some bacteria or parasites. It plays a criti­cal role in capturing and internalizing those pathogens. LSP1 (leukocyte-specific protein 1) interacts with the cytoplasmic domain of CD209 and mediates transport of HIV to the proteasome.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
CD209 protein structure - 330102 shown in red.