FNab09938

antibody from FineTest Biotech

Targeting: CASP3 apopain, CPP32, CPP32B, Yama

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Validation data

Product number: FNab09938 - Provider product page
Provider: FineTest Biotech
Product name: CASP3 antibody
Antibody type: Monoclonal
Antigen: Recombinant protein fragment
Description: Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: caspase 3, apoptosis-related cystei ne peptidase
Epitope: IgG1
Isotype: IgG
Antibody clone number: 2G7
Vial size: 100¦Ìg
Concentration: protein A+G purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

CASP3 protein structure - FNab09938 shown in red.