BS7917

antibody from Bioworld Technology, Inc
Targeting: POLK DINB1, DINP, POLQ
Provider product page for BS7917
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7917 - Provider product page
Provider
Bioworld Technology, Inc
Product name
POLK polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human POLK.
Description
Problems in DNA replication may lead to breaks in the replication fork, and recombinational reactions occur to restore the integrity of the fork via strand-invasion of the broken chromosome with its homologous strand. If this happens within repeated DNA sequences, genetic rearrangements may be produced. The bacterial UmuC/DinB family consists of bypass polymerases that are responsible for translesion DNA synthesis. DinB, also referred to as DNA polyermase IV or DNA polymerase k, is an SOS-inducible, error-prone DNA polymerase that plays a role in DNA damage-induced mutagenesis by preferentially making frameshift mutations. DinB is uniquely and highly expressed in the adrenal cortex and testis, as well as in a variety of other tissues. p53 regulates DinB and exposure to various DNA-damaging agents causes an upregulation of DinB.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
POLK protein structure - BS7917 shown in red.