F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Description

Coagulation factor II thrombin receptor like 2

Tissue specificity

Tissue enhanced (gallbladder)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

5 (76615482 - 76623413)

Ensembl ID

ENSG00000164220  (ver. 103.38)

Orthologs

Mouse F2rl2: ENSMUSG00000021675

UniProt

O00254

neXtProt

NX_O00254

Human splice variants
Mouse splice variants

Protein structure