GGA2

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

Description

Golgi associated, gamma adaptin ear containing, ARF binding protein 2

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (23463542 - 23521995)

Ensembl ID

ENSG00000103365  (ver. 103.38)

Orthologs

Mouse Gga2: ENSMUSG00000030872

UniProt

Q9UJY4

neXtProt

NX_Q9UJY4

Human splice variants
Mouse splice variants

Protein structure