BS8003

antibody from Bioworld Technology, Inc
Targeting: SDHB SDH, SDH1
Provider product page for BS8003
Western blot
Immunohistochemistry

Antibody data

Product number
BS8003 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SDHB polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SDHB.
Description
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations associate with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SDHB protein structure - BS8003 shown in red.