335101

antibody from BioLegend
Targeting: CXCR6 BONZO, CD186, STRL33, TYMSTR
Provider product page for 335101

Antibody data

Product number
335101 - Provider product page
Provider
BioLegend
Product name
Alexa Fluor® 647 anti-human CD186 (CXCR6) [TG3/CXCR6]
Antibody type
Monoclonal
Antigen
CD186 (CXCR6)
Description
CXCR6 is a chemokine receptor that binds CXCL16. It is expressed in Th1 inflammatory diseases such as rheumatoid arthritis (3) and Grave’s disease (4) among others. Th1 cells isolated from the bronchoalveolar lavage of patients with sarcoidosis and T-cell alveolitis coexpressed CXCR3 and CXCR6. The CXCR6 ligand CXCL16 was abundantly expressed by macrophages infiltrating sarcoid tissue and/or forming the granuloma core (5). Recent data showed that CXCR6 is expressed on polymorphonuclear neutrophils in pancreatic carcinoma and in acute localized bacterial infections. CXCR6 is not constitutively expressed on PMN, but is up-regulated under inflammatory conditions and mediates migration of CXCR6-positive PMN (6). Fetus-derived trophoblasts can attract T cells, gamma delta T cells, and monocytes by producing CXCL16 and interaction with CXCR6 on these cells, leading to forming a specialized immune milieu at the maternofetal interface (7).
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
CXCR6 protein structure - 335101 shown in red.