BS7726

antibody from Bioworld Technology, Inc
Targeting: OAS1 IFI-4, OIAS, OIASI
Provider product page for BS7726
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7726 - Provider product page
Provider
Bioworld Technology, Inc
Product name
OAS1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human OAS1.
Description
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
OAS1 protein structure - BS7726 shown in red.