FNab05949

antibody from FineTest Biotech
Targeting: OAS1 IFI-4, OIAS, OIASI
Provider product page for FNab05949
Western blot
ELISA
Immunohistochemistry

Antibody data

Product number
FNab05949 - Provider product page
Provider
FineTest Biotech
Product name
OAS1 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus(VSV), herpes simplex virus type 2(HSV-2), and encephalomyocarditis virus(EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
2',5'-oligoadenylate synthetase 1,
40/46kDa
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
OAS1 protein structure - FNab05949 shown in red.