AMN

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

Description

Amnion associated transmembrane protein

Tissue specificity

Group enriched (intestine, kidney, liver)

Predicted location

Intracellular, Membrane, Secreted in other tissues

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (102922663 - 102933596)

Ensembl ID

ENSG00000166126  (ver. 103.38)

Orthologs

Mouse Amn: ENSMUSG00000021278

UniProt

Q9BXJ7

neXtProt

NX_Q9BXJ7

Human splice variants
Mouse splice variants

Protein structure