650302

antibody from BioLegend
Targeting: CAMP CAP18, FALL-39, FALL39, LL37
Provider product page for 650302
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
650302 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#650302, RRID:AB_10708096
Product name
Purified anti-CAP-18
Antibody type
Monoclonal
Antigen
Partially purified human neutrophil membrane proteins, with epitope mapping to amino acids 115-121
Description
Antimicrobial peptides (AMP) are effector molecules of the innate immune system with direct antimicrobioal and immunomodulatory effects. AMP are produced by epithelial and professional host defense cells such as macrophages or neutrophils. AMP directly inactivate microorganisms and, in addition, have diverse activities on various cell types. In mammals, peptides of the defensin and the cathelicidin families are found.  hCAP-18 is the only cathelicidin present in humans. hCAP-18 is a 170 amino acid cathelicidin anti-microbial precursor protein that is proteolytically processed to yield the antibacterial peptide LL-37. The precursor hCAP-18 is found in the specific granules of neutrophils and is expressed in many immune and epithelial cells. Cathelicidin has an established role in host defense. In addition to their direct antimicrobial function, cathelicidin peptides are involved in the modulation of repair and tissue homeostasis, epithelial wound healing, chemoattraction of immune cells, and release of inflammatory mediators from epithelial cells. Recent studies also found that LL-37 significantly regulates endocytic capacity, modifies expression of phagocytic receptors, increases secretion of Th1-inducing cytokines of dendritic cells (DC) generated from blood monocytes, and modulates the response of monocytes and DC to toll like receptor (TLR)–ligands. Moreover LL-37 also modulates the response of neutrophils to bacterial activation.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Upon receipt, store undiluted at 4°C.
CAMP protein structure - 650302 shown in red.