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- Antibody Data
- Antigen structure
- References [77]
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- Western blot [1]
- Immunocytochemistry [2]
- Immunoprecipitation [1]
- Flow cytometry [1]
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- Product number
- 13057-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13057-2-AP, RRID:AB_2232034
- Product name
- G3BP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated G3BP1 antibody (Cat. #13057-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells.
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Capturing RNA-protein interaction via CRUIS.
Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis.
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptidesin Semi-permeabilized Human Cells.
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer.
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
m6A enhances the phase separation potential of mRNA.
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival.
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.
G3BP1 promotes DNA binding and activation of cGAS.
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1.
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer.
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS).
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571
Frontiers in veterinary science 2021;8:645571
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.
Fortuna TR, Kour S, Anderson EN, Ward C, Rajasundaram D, Donnelly CJ, Hermann A, Wyne H, Shewmaker F, Pandey UB
Acta neuropathologica 2021 Sep;142(3):515-536
Acta neuropathologica 2021 Sep;142(3):515-536
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
Dai B, Zhong T, Chen ZX, Chen W, Zhang N, Liu XL, Wang LQ, Chen J, Liang Y
The Journal of biological chemistry 2021 Oct;297(4):101222
The Journal of biological chemistry 2021 Oct;297(4):101222
c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.
Li B, Zhang G, Wang Z, Yang Y, Wang C, Fang D, Liu K, Wang F, Mei Y
Cell death & disease 2021 Oct 27;12(11):1006
Cell death & disease 2021 Oct 27;12(11):1006
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Park J, Lee J, Kim JH, Lee J, Park H, Lim C
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells.
Yu NK, McClatchy DB, Diedrich JK, Romero S, Choi JH, Martínez-Bartolomé S, Delahunty CM, Muotri AR, Yates JR 3rd
iScience 2021 Nov 19;24(11):103321
iScience 2021 Nov 19;24(11):103321
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y
Diabetologia 2021 May;64(5):1144-1157
Diabetologia 2021 May;64(5):1144-1157
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
Ciccosanti F, Di Rienzo M, Romagnoli A, Colavita F, Refolo G, Castilletti C, Agrati C, Brai A, Manetti F, Botta L, Capobianchi MR, Ippolito G, Piacentini M, Fimia GM
Antiviral research 2021 Jun;190:105064
Antiviral research 2021 Jun;190:105064
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.
Luo L, Li Z, Zhao T, Ju X, Ma P, Jin B, Zhou Y, He S, Huang J, Xu X, Zou Y, Li P, Liang A, Liu J, Chi T, Huang X, Ding Q, Jin Z, Huang C, Zhang Y
Science bulletin 2021 Jun 30;66(12):1194-1204
Science bulletin 2021 Jun 30;66(12):1194-1204
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
Baade I, Hutten S, Sternburg EL, Pörschke M, Hofweber M, Dormann D, Kehlenbach RH
The Journal of biological chemistry 2021 Jan-Jun;296:100659
The Journal of biological chemistry 2021 Jan-Jun;296:100659
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD
Nature structural & molecular biology 2021 Feb;28(2):132-142
Nature structural & molecular biology 2021 Feb;28(2):132-142
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
Park J, Chang J, Hwang HJ, Jeong K, Lee HJ, Ha H, Park Y, Lim C, Woo JS, Kim YK
Nucleic acids research 2021 Dec 2;49(21):12517-12534
Nucleic acids research 2021 Dec 2;49(21):12517-12534
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Di Tomasso G, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Vande Velde C
Brain : a journal of neurology 2021 Dec 16;144(11):3461-3476
Brain : a journal of neurology 2021 Dec 16;144(11):3461-3476
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J
Cellular and molecular neurobiology 2021 Aug 4;
Cellular and molecular neurobiology 2021 Aug 4;
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S
Cell 2021 Aug 19;184(17):4547-4563.e17
Cell 2021 Aug 19;184(17):4547-4563.e17
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Arenas A, Chen J, Kuang L, Barnett KR, Kasarskis EJ, Gal J, Zhu H
Human molecular genetics 2020 Sep 29;29(16):2684-2697
Human molecular genetics 2020 Sep 29;29(16):2684-2697
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network.
Lin H, Xie J, Fan T, He Y, Chen J, Zhang H, Zhuo S
Nanoscale 2020 Nov 26;12(45):23134-23139
Nanoscale 2020 Nov 26;12(45):23134-23139
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Capturing RNA-protein interaction via CRUIS.
Zhang Z, Sun W, Shi T, Lu P, Zhuang M, Liu JL
Nucleic acids research 2020 May 21;48(9):e52
Nucleic acids research 2020 May 21;48(9):e52
Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?
Hoch-Kraft P, Trotter J, Gonsior C
Neurochemical research 2020 Mar;45(3):566-579
Neurochemical research 2020 Mar;45(3):566-579
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Hicks DA, Cross LL, Williamson R, Rattray M
Neurochemical research 2020 Jun;45(6):1354-1364
Neurochemical research 2020 Jun;45(6):1354-1364
Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis.
Luotti S, Pasetto L, Porcu L, Torri V, Elezgarai SR, Pantalone S, Filareti M, Corbo M, Lunetta C, Mora G, Bonetto V
Neurobiology of disease 2020 Jun;139:104815
Neurobiology of disease 2020 Jun;139:104815
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Lo LH, Dong R, Lyu Q, Lai KO
Cell reports 2020 Jun 9;31(10):107744
Cell reports 2020 Jun 9;31(10):107744
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Rao L, Xu Y, Reineke LC, Bhattacharya A, Tyryshkin A, Shin JN, Eissa NT
International journal of molecular sciences 2020 Jun 17;21(12)
International journal of molecular sciences 2020 Jun 17;21(12)
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
Tsai YL, Coady TH, Lu L, Zheng D, Alland I, Tian B, Shneider NA, Manley JL
Genes & development 2020 Jun 1;34(11-12):785-805
Genes & development 2020 Jun 1;34(11-12):785-805
ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.
Lee DY, Jeon GS, Sung JJ
Neurochemical research 2020 Dec;45(12):2884-2893
Neurochemical research 2020 Dec;45(12):2884-2893
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C
PLoS biology 2020 Dec;18(12):e3001002
PLoS biology 2020 Dec;18(12):e3001002
A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptidesin Semi-permeabilized Human Cells.
Hutten S, Dormann D
Bio-protocol 2020 Dec 20;10(24):e3846
Bio-protocol 2020 Dec 20;10(24):e3846
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer.
Xiong R, Gao JL, Yin T
OncoTargets and therapy 2019;12:7149-7156
OncoTargets and therapy 2019;12:7149-7156
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME
Cell 2019 Sep 19;179(1):147-164.e20
Cell 2019 Sep 19;179(1):147-164.e20
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
Gal J, Chen J, Na DY, Tichacek L, Barnett KR, Zhu H
Molecular and cellular biology 2019 Nov 15;39(22)
Molecular and cellular biology 2019 Nov 15;39(22)
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M
Molecular cell 2019 May 16;74(4):742-757.e8
Molecular cell 2019 May 16;74(4):742-757.e8
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
Tischbein M, Baron DM, Lin YC, Gall KV, Landers JE, Fallini C, Bosco DA
The Journal of biological chemistry 2019 Jun 28;294(26):10194-10210
The Journal of biological chemistry 2019 Jun 28;294(26):10194-10210
m6A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR
Nature 2019 Jul;571(7765):424-428
Nature 2019 Jul;571(7765):424-428
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M
Nature communications 2019 Jul 2;10(1):2909
Nature communications 2019 Jul 2;10(1):2909
Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival.
Wang S, Kwon SH, Su Y, Dong Z
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F116-F123
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F116-F123
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA
Human molecular genetics 2019 Jul 1;28(13):2143-2160
Human molecular genetics 2019 Jul 1;28(13):2143-2160
STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.
Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):286-300
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):286-300
G3BP1 promotes DNA binding and activation of cGAS.
Liu ZS, Cai H, Xue W, Wang M, Xia T, Li WJ, Xing JQ, Zhao M, Huang YJ, Chen S, Wu SM, Wang X, Liu X, Pang X, Zhang ZY, Li T, Dai J, Dong F, Xia Q, Li AL, Zhou T, Liu ZG, Zhang XM, Li T
Nature immunology 2019 Jan;20(1):18-28
Nature immunology 2019 Jan;20(1):18-28
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Franchini DM, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, Scarlata CM, Lebras M, Rossi C, Ligat L, Pont F, Arimondo PB, Laurent C, Ayyoub M, Despas F, Lapeyre-Mestre M, Millevoi S, Fournié JJ
Cell reports 2019 Jan 2;26(1):94-107.e7
Cell reports 2019 Jan 2;26(1):94-107.e7
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
Cai D, Feliciano D, Dong P, Flores E, Gruebele M, Porat-Shliom N, Sukenik S, Liu Z, Lippincott-Schwartz J
Nature cell biology 2019 Dec;21(12):1578-1589
Nature cell biology 2019 Dec;21(12):1578-1589
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C, Soares-Cunha C, Mazuik BF, Takashima A, Ludovico P, Wolozin B, Sousa N, Sotiropoulos I
Cell death and differentiation 2019 Aug;26(8):1411-1427
Cell death and differentiation 2019 Aug;26(8):1411-1427
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ
Neuron 2019 Apr 17;102(2):321-338.e8
Neuron 2019 Apr 17;102(2):321-338.e8
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N, Gramberg T
Mobile DNA 2018;9:11
Mobile DNA 2018;9:11
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Zhang X, Shu XE, Qian SB
Nature chemical biology 2018 Oct;14(10):909-916
Nature chemical biology 2018 Oct;14(10):909-916
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.
Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM, Dormann D
Scientific reports 2018 May 4;8(1):7084
Scientific reports 2018 May 4;8(1):7084
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
Ramachandran B, Stabley JN, Cheng SL, Behrmann AS, Gay A, Li L, Mead M, Kozlitina J, Lemoff A, Mirzaei H, Chen Z, Towler DA
The Journal of biological chemistry 2018 May 25;293(21):7942-7968
The Journal of biological chemistry 2018 May 25;293(21):7942-7968
TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
Lee Y, Jonson PH, Sarparanta J, Palmio J, Sarkar M, Vihola A, Evilä A, Suominen T, Penttilä S, Savarese M, Johari M, Minot MC, Hilton-Jones D, Maddison P, Chinnery P, Reimann J, Kornblum C, Kraya T, Zierz S, Sue C, Goebel H, Azfer A, Ralston SH, Hackman P, Bucelli RC, Taylor JP, Weihl CC, Udd B
The Journal of clinical investigation 2018 Mar 1;128(3):1164-1177
The Journal of clinical investigation 2018 Mar 1;128(3):1164-1177
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC
Molecular cell 2018 Feb 1;69(3):517-532.e11
Molecular cell 2018 Feb 1;69(3):517-532.e11
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D
Cell 2018 Apr 19;173(3):706-719.e13
Cell 2018 Apr 19;173(3):706-719.e13
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1.
Reineke LC, Tsai WC, Jain A, Kaelber JT, Jung SY, Lloyd RE
Molecular and cellular biology 2017 Feb 15;37(4)
Molecular and cellular biology 2017 Feb 15;37(4)
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Mitsuhashi K, Ito D, Mashima K, Oyama M, Takahashi S, Suzuki N
Scientific reports 2017 Dec 4;7(1):16871
Scientific reports 2017 Dec 4;7(1):16871
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Cifuentes-Muñoz N, Branttie J, Slaughter KB, Dutch RE
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.
Kuang L, Kamelgarn M, Arenas A, Gal J, Taylor D, Gong W, Brown M, St Clair D, Kasarskis EJ, Zhu H
Neurology. Genetics 2017 Aug;3(4):e172
Neurology. Genetics 2017 Aug;3(4):e172
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N
Brain : a journal of neurology 2016 Sep;139(Pt 9):2380-94
Brain : a journal of neurology 2016 Sep;139(Pt 9):2380-94
ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.
Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ, Zhu H
Acta neuropathologica 2016 Oct;132(4):563-76
Acta neuropathologica 2016 Oct;132(4):563-76
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Rodriguez-Ortiz CJ, Flores JC, Valenzuela JA, Rodriguez GJ, Zumkehr J, Tran DN, Kimonis VE, Kitazawa M
The American journal of pathology 2016 Jun;186(6):1623-34
The American journal of pathology 2016 Jun;186(6):1623-34
Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.
Xia Q, Wang G, Wang H, Hu Q, Ying Z
Human molecular genetics 2016 Jan 1;25(1):83-96
Human molecular genetics 2016 Jan 1;25(1):83-96
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB
Acta neuropathologica 2016 Apr;131(4):605-20
Acta neuropathologica 2016 Apr;131(4):605-20
Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer.
Deng W, Yan M, Yu T, Ge H, Lin H, Li J, Liu Y, Geng Q, Zhu M, Liu L, He X, Yao M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(5):1677-88
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(5):1677-88
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.
Nielsen CT, Østergaard O, Rekvig OP, Sturfelt G, Jacobsen S, Heegaard NH
Lupus 2015 Oct;24(11):1150-60
Lupus 2015 Oct;24(11):1150-60
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G, Ying Z
Human molecular genetics 2015 May 1;24(9):2426-41
Human molecular genetics 2015 May 1;24(9):2426-41
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Yamakawa M, Ito D, Honda T, Kubo K, Noda M, Nakajima K, Suzuki N
Human molecular genetics 2015 Mar 15;24(6):1630-45
Human molecular genetics 2015 Mar 15;24(6):1630-45
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C, Guo F
PLoS genetics 2015 Jul;11(7):e1005367
PLoS genetics 2015 Jul;11(7):e1005367
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Baron DM, Kaushansky LJ, Ward CL, Sama RR, Chian RJ, Boggio KJ, Quaresma AJ, Nickerson JA, Bosco DA
Molecular neurodegeneration 2013 Aug 31;8:30
Molecular neurodegeneration 2013 Aug 31;8:30
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT
PloS one 2012;7(6):e38658
PloS one 2012;7(6):e38658
Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS).
Nihei Y, Ito D, Suzuki N
The Journal of biological chemistry 2012 Nov 30;287(49):41310-23
The Journal of biological chemistry 2012 Nov 30;287(49):41310-23
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Ito D, Seki M, Tsunoda Y, Uchiyama H, Suzuki N
Annals of neurology 2011 Jan;69(1):152-62
Annals of neurology 2011 Jan;69(1):152-62
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N
The Journal of biological chemistry 2010 Jan 1;285(1):608-19
The Journal of biological chemistry 2010 Jan 1;285(1):608-19
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 13057-2-AP(G3BP1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 13057-2-AP( G3BP1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 13057-2-AP( G3BP1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-G3BP1 (IP:13057-2-AP, 3ug; Detection:13057-2-AP 1:1000) with HEK-293 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The G3BP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human G3BP1. This antibody recognizes human,mouse,rat antigen. The G3BP1 antibody has been validated for the following applications: ELISA, WB, IP, IF, IHC, FC analysis.
