CYP2D6

gene product
CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, P450-DB1, P450C2D
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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377 antibodies from 27 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
antibodies-online
132 antibodies
NovoPro Bioscience Inc.
4 antibodies
LifeSpan BioSciences, Inc.
53 antibodies
Aviva Systems Biology
11 antibodies
Proteintech Group
2 antibodies
Novus Biologicals
6 antibodies
Abnova Corporation
7 antibodies
Invitrogen Antibodies
4 antibodies
Abgent
2 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
3 antibodies
Biorbyt
45 antibodies
Cell Signaling Technology, Inc
1 antibody
Acris Antibodies GmbH
8 antibodies
RabMAbs
2 antibodies
BosterBio
1 antibody
NSJ Bioreagents
1 antibody
MyBioSource
12 antibodies
Creative Biolabs
3 antibodies
GeneTex
3 antibodies
St John's Laboratory
6 antibodies
United States Biological
50 antibodies
Enzo Life Sciences
2 antibodies
GenWay
3 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
1 antibody