BS8650

antibody from Bioworld Technology, Inc
Targeting: COPS3 CSN3, SGN3
Provider product page for BS8650
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8650 - Provider product page
Provider
Bioworld Technology, Inc
Product name
COPS3 polyclonal antibody
Antibody type
Polyclonal
Antigen
COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3; AB1-containing signalosome subunit 3; COPS 3; CSN3
Description
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I?BÏ« and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
COPS3 protein structure - BS8650 shown in red.