Tissue expression
Cell line expression
Protein structure
NPC1L1
NPC1 like intracellular cholesterol transporter 1SLC65A2
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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Novus Biologicals | NB400-127 | 13 references | Polyclonal |
WB
EL
ICC
IHC
IEM
|
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Invitrogen Antibodies | PA1-16800 | 2 references | Polyclonal |
WB
EL
IHC
IEM
OA
|
|
antibodies-online | ABIN268863 | 12 references | Polyclonal |
WB
ICC
IHC
IEM |
|
NSJ Bioreagents | RQ6664 | Polyclonal |
WB
EL
ICC
FC |
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GeneTex | GTX30599 | Polyclonal |
WB
ICC
IHC
IEM |
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Supportive data in Antibodypedia
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Recommended by provider