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Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W
Nature 2014 Apr 24;508(7497):541-5

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.

Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L
Cancer cell 2013 Feb 11;23(2):228-37

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y
Nature medicine 2012 Oct;18(10):1560-9

PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.

Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA
American journal of physiology. Renal physiology 2012 May 1;302(9):F1210-23

Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.

Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE
Blood 2012 Mar 29;119(13):3155-63

AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell.

Jothi M, Nishijo K, Keller C, Mal AK
Cell cycle (Georgetown, Tex.) 2012 Mar 1;11(5):895-908

Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.

Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK
Molecular cell 2011 Sep 2;43(5):723-37

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT
Cell 2011 Sep 2;146(5):697-708

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K
Cancer cell 2011 Sep 13;20(3):400-13

Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.

Cheung R, Shen F, Phillips JH, McGeachy MJ, Cua DJ, Heyworth PG, Pierce RH
The Journal of clinical investigation 2011 Nov;121(11):4446-61

Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing.

Siemens N, Patenge N, Otto J, Fiedler T, Kreikemeyer B
The Journal of biological chemistry 2011 Jun 17;286(24):21612-22

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.

Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
Nature medicine 2011 Jul 31;17(8):944-51

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM
Cancer cell 2009 Feb 3;15(2):148-59

Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.

Allard D, Figg N, Bennett MR, Littlewood TD
The Journal of biological chemistry 2008 Jul 11;283(28):19739-47

Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver.

Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS, Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM
Journal of the National Cancer Institute 2008 Jan 16;100(2):109-20

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK
Nature medicine 2008 Dec;14(12):1351-6

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.

Fos C, Salles A, Lang V, Carrette F, Audebert S, Pastor S, Ghiotto M, Olive D, Bismuth G, Nunès JA
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1969-77

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