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- Antigen structure
- References [11]
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- Product number
- 4691 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#4691, RRID:AB_915783
- Product name
- Akt (pan) (C67E7) Rabbit mAb
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat, Drosophila, Simian
- Host
- Rabbit
- Storage
- -20°C
Submitted references Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell.
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.
Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver.
Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L
Cancer cell 2013 Feb 11;23(2):228-37
Cancer cell 2013 Feb 11;23(2):228-37
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA
American journal of physiology. Renal physiology 2012 May 1;302(9):F1210-23
American journal of physiology. Renal physiology 2012 May 1;302(9):F1210-23
AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell.
Jothi M, Nishijo K, Keller C, Mal AK
Cell cycle (Georgetown, Tex.) 2012 Mar 1;11(5):895-908
Cell cycle (Georgetown, Tex.) 2012 Mar 1;11(5):895-908
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
Yang S, Xiao X, Meng X, Leslie KK
PloS one 2011;6(10):e26343
PloS one 2011;6(10):e26343
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
Nature medicine 2011 Jul 31;17(8):944-51
Nature medicine 2011 Jul 31;17(8):944-51
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M
The Journal of biological chemistry 2011 Dec 9;286(49):42162-79
The Journal of biological chemistry 2011 Dec 9;286(49):42162-79
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.
Fonseca BD, Alain T, Finestone LK, Huang BP, Rolfe M, Jiang T, Yao Z, Hernandez G, Bennett CF, Proud CG
The Journal of biological chemistry 2011 Aug 5;286(31):27111-22
The Journal of biological chemistry 2011 Aug 5;286(31):27111-22
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP
PloS one 2010 Mar 19;5(3):e9646
PloS one 2010 Mar 19;5(3):e9646
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M
The American journal of pathology 2010 Jul;177(1):415-23
The American journal of pathology 2010 Jul;177(1):415-23
Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.
Allard D, Figg N, Bennett MR, Littlewood TD
The Journal of biological chemistry 2008 Jul 11;283(28):19739-47
The Journal of biological chemistry 2008 Jul 11;283(28):19739-47
Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver.
Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS, Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM
Journal of the National Cancer Institute 2008 Jan 16;100(2):109-20
Journal of the National Cancer Institute 2008 Jan 16;100(2):109-20
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