Ab087937

antibody from Aladdin Scientific Corporation
Targeting: AKT1 AKT, PKB, PRKBA, RAC, RAC-alpha
Provider product page for Ab087937
Western blot
ELISA
Immunocytochemistry

Antibody data

Product number
Ab087937 - Provider product page
Provider
Aladdin Scientific Corporation
Product name
AKT1 Mouse mAb
Antibody type
Monoclonal
Description
Application:WB: 1/500 - 1/2000.  IF/ICC: 1/200 - 1/1000 Flow: 1/200 - 1/400ELISA: 1/10000Protein Function：Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Reactivity
Human, Mouse, Rat, Simian
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA: 1-150
Isotype
IgG
Antibody clone number
1F7E10
Vial size
100μl,10μl,1ml,50μl
Concentration
1 mg/ml
Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
AKT1 protein structure - Ab087937 shown in red.