BS1862

antibody from Bioworld Technology, Inc
Targeting: TNFRSF11B OCIF, OPG, TR1
Provider product page for BS1862
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1862 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1862, RRID:AB_1663697
Product name
OPG (P25) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 1-50 of Human OPG.
Description
The cytokine osteoprotegerin(OPG), also designated osteoclastogenesis inhibitory factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFÏ« and TNFÉÇ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TNFRSF11B protein structure - BS1862 shown in red.