4249

antibody from Cell Signaling Technology, Inc

Targeting: PIK3CA PI3K

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

4249

Provider

Cell Signaling Technology, Inc

Proper citation

Cell Signaling Technology Cat#4249, RRID:AB_2165248

Product name

PI3 Kinase p110α (C73F8) Rabbit mAb

Antibody type

Monoclonal

Reactivity

Human, Mouse, Rat, Bovine

Host

Rabbit

Storage

-20°C

References

Submitted references

Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells.

Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa Y
The Journal of biological chemistry 2013 Jan 25;288(4):2325-39

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Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y
Nature medicine 2012 Oct;18(10):1560-9

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Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.

Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ
The Journal of biological chemistry 2010 Dec 31;285(53):41337-47

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The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K
Science signaling 2010 Aug 10;3(134):ra60