BS3456

antibody from Bioworld Technology, Inc

Targeting: PIK3CA PI3K

Immunohistochemistry

Antibody data

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Validation data

Product number: BS3456 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS3456, RRID:AB_1661933
Product name: PI3K p110Ï« (R519) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 500-550 of Human PI3K p110Ï«.
Description: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85Ï« and p85ÉÇ), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110Ï« and p110ÉÇ interact with p85Ï«, and p110Ï« has also been shown to interact with p85ÉÇ in vitro. p110Ñ´ expression is restricted to white blood cells. It has been shown to bind p85Ï« and ÉÇ, but it apparently does not phosphorylate these subunits. p110Ñ´ seems to have the capacity to autophosphorylate. p110ÎÛ does not interact with the p85 subunits. It has been shown to be activated by Ï« and ÉÇÎÛ heterotrimeric G proteins.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

PIK3CA protein structure - BS3456 shown in red.