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Protein structure
NPPB
Natriuretic peptide BThis gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| LSBio |  LS-C370671 |
Polyclonal |
WB
EL
IHC
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| Antibodies.com | A52992 |
Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | H00004879-M01 |
1 references | Monoclonal |
WB
EL
IP
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| Invitrogen Antibodies | PA5-96084 |
1 references | Polyclonal |
WB
ICC
IHC
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| Proteintech Group | 13299-1-AP |
12 references | Polyclonal |
EL
IHC
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