BS8341

antibody from Bioworld Technology, Inc
Targeting: NLK
Provider product page for BS8341
Western blot
Immunohistochemistry

Antibody data

Product number
BS8341 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NLK polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NLK.
Description
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2 , respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif . Phosphorylation at both Thr-183 and Tyr-185 is required for full enzymatic activation . In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Nlk, or nemo-like kinase, is a murine homolog of the Drosophila nemo (nmo) gene. Nlk and Nmo have sequence homology to both the ERK MAP kinases and the cyclin dependent kinases. Nlk is a nuclear protein with the ability to autophosphorylate .
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NLK protein structure - BS8341 shown in red.