11-7501-25

antibody from ABEOMICS Inc.
Targeting: BRD4 CAP, HUNK1, HUNKI, MCAP
Provider product page for 11-7501-25

Antibody data

Product number
11-7501-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-BRD4, HUNK1 Antibody
Antibody type
Polyclonal
Description
BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. A chromosomal aberration involving BRD4 is found in a rare, aggressive and lethal carcinoma arising in midline organs of young people. It expressed ubiquitously and has three isoforms. Isoform B acts as a chromatin insulator in the DNA damage response pathway.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant BRD4 p
rotein (amino acids 140-500) was us
ed as the immunogen for this antibo
dy.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
BRD4 protein structure - 11-7501-25 shown in red.