Ab111970

antibody from Aladdin Scientific Corporation

Targeting: KEAP1 INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab111970

Provider

Aladdin Scientific Corporation

Product name

Recombinant Keap1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Keap1 Antibody, Recombinant (R02-1H7) , could be used for WB, IHC and so on.Application:WB: 1/500 - 1/1000IHC : 1/50 - 1/100Protein FunctionRetains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.Post-translationalUbiquitinated and subject to proteasomal degradation.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 321-609


Antibody clone number

R02-1H7

Vial size

100μl,10μl,1ml,50μl

Concentration

0,9 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.