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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 651602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#651602, RRID:AB_11125367
- Product name
- Purified anti-ZBP-1
- Antibody type
- Monoclonal
- Antigen
- Recombinant human ZBP-1, antibody recognizing Zbeta domain
- Description
- Z-DNA binding protein 1 (ZBP-1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RAN. Vertebrate ZBPs are induced by immunostimulation and are involved in host defense mechanisms. ZBP-1 initiates an innate immune response by binding to foreign DNA in the cytosol. ZBP-1 mediates activation of the innate immune system by facilitating DNA-mediated induction of type-1 IFN and expression of other related genes. Human ZBP-1 is most prominently expressed in lymphatic tissues. Besides its function in immunoresponse, it is up-regulated in mouse tumor stromal cells and is speculated to play a role in host defense again tumors.
- Reactivity
- Human
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store undiluted at 4°C.
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Extracts of 293E cells notransfected (Lane A) and transfected with hZBP-1 (Lane B) were resolved by eletrophoresis, trasferred to nitrocellulose, and probed with anti-hZBP-1 antibody (clone RONOB19). Proteins were visualized using a goat anti-rat IgG secondary conjugated to HRP and chemiluminescence detection.
- Conjugate
- Unconjugated
